Objective To explore the significance of combined detection of CEA, CA125, CA153 and CA199 in differential diagnosis of benign and malignant ascites. Methods Chemiluminescence immunoassay was applied for examination of levels of CEA, CA125, CA153, CA199 in ascites of patients, and their results were statistically analyzed. Results The levels of CEA, CA125, CA153 and CA199 in malignant ascites were significantly higher than those of benign ascites ( P <0.01 ). Their sensitivity was 89.3% , specificity was 96.7% , and the accuracy of joint detection was 91.9% There was significant difference ( P <0.05 ) in comparison with the single test. Conclusion The combined detection of levels of CEA, CA125, CA153 and CA199 has prognostic value in differential diagnosis of benign and malignant ascites.%目的 探讨癌胚抗原(CEA)、癌抗原125(CA125)、癌抗原153(CA153)、癌抗原199(CA199)联合检测在良恶性腹水鉴别诊断中的价值.方法 应用化学发光免疫法检测病人腹水中CEA、CA125、CA153、CA199含量,并对结果进行统计学处理.结果 恶性组和良性组比较,恶性组腹水中CEA、CA125、CA153、CA199浓度明显高于良性组(P<0.01).CEA、CA125、CA153、CA199联合检测,敏感性89.3%,特异性96.7%,准确性91.9%,与单一检测比较,差异均有显著性(P＜0.05).结论 CEA、CA125、CA153、CA199联合检测对良恶性腹水的鉴别具有一定的临床价值.
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