大蒜素在鲫鱼体内的药动学及残留消除规律

摘要

The pharmacokinetics and residues of allicin were studied in crucian carp exposed to oral administration at 7. 5 mg/kg body-weight by means of gas chromatography ( GC) . The results showed that the concentrations versus time of allicin in muscle was well de-scribed by two-department open model with first-order absorption after a single oral administration. The residues in crucian carp by oral administration for 3 d once a day were found to be less than the maximum residue limit (MRL) (10 μg/kg) at the day 13 for DADS and the day 15 for DATS. The findings indicated that the withdrawal time should be 15 days after administration on these conditions.%采用气相色谱法,研究了以7.5 mg/kg(体质量)单次剂量口灌给药后,大蒜素在鲫鱼体内的药物代谢动力学及药物残留消除规律.结果表明:单次口灌给药后,大蒜素在血浆中的药时关系符合一级吸收二室开放模型.每天一次,连续3 d给药后,大蒜素的主要成分:二烯丙基二硫醚(DADS)于13 d开始低于10μg/kg,二烯丙基三硫醚(DATS)于15 d开始低于10μg/kg.研究表明,建议休药期不低于15 d.