Sox4和E-cadherin在子宫颈鳞状细胞癌中的表达及临床意义

摘要

Objective:To investigate the expression levels of SRY-related HMG-box 4(Sox4)and epithelial-mesenchymal transition related protein E-cadherin in cervical squamous cell carcinoma(CSCC),and their clinical significance.Methods:The expression levels of Sox4 and E-cadherin proteins in CSCC group(160 cases)and control group(28 cases)were detected by S-P immunohistochemical method,and the relationships between which and clinicopathological parameters were analyzed.Results:The positive rate of Sox4 in observation group(63.75％)was higher than that in control group(39.29％)(P 0.05).Conclusions:Sox4 may promote the occurrence,development,invasion and metastasis of CSCC by down-regulating the E-cadherin protein.The combined detection of Sox4 and E-cadherin can provide the reference in early diagnosis,treatment and predicting the prognosis of patients with CSCC.%目的:研究转录因子Sox4和上皮间质转化相关蛋白上皮型钙黏蛋白(E-cadherin)在子宫颈鳞状细胞癌(CSCC)中的表达及相关性,为临床的诊断和治疗提供依据.方法:将160例CSCC定义为观察组,28例癌旁组织定义为对照组,利用免疫组织化学S-P法,检验2组Sox4和E-cadherin蛋白表达及其与临床病理参数之间的关系.结果:Sox4在观察组阳性率为63.75％,高于对照组的39.29％(P0.05).结论:Sox4可能通过下调E-cadherin促进CSCC发生、发展、侵袭和转移,联合检测二者可为CSCC的早期诊断、治疗和预后提供参考.