难治性癫(癎)多药耐药机制的研究进展

摘要

多药物抵抗是药物治疗难治性癫(癎)的主要障碍.有研究表明,多药物转运子P糖蛋白的表达增加和活性增强,阻止抗癫(癎)药物进入大脑是多药物抵抗的主要机制.另外有研究发现P糖蛋白的表达和活性与谷氨酸盐/NMDA受体/COX-2信号途径有关,这可能成为新的解决癫(癎)多药物抵抗的靶点.%Multidrug resistance is a major obstacle in the chemotherapy of refractory epilepsy.P-glycoprotein,an efflux transporter,which may play an important role in refractory epilepsy.Some studies point out that increased P-glycoprotein expression and,activity limit pharmacotherapy with antiepileptic drugs.Other studies indicate that glutamate released during seizures signals through the NMDA receptor and COX-2 to increase P-glycoprotein.These evidences may lead to a new therapy of drug-resistantepilepsy.