通天草提取物对阿尔茨海默病大鼠脑氧化性损伤的保护作用

摘要

目的:探讨通天草提取物对阿尔茨海默病大鼠脑氧化性损伤的保护作用.方法:以Aβ诱导大鼠老年痴呆为研究模型,探讨了通天草两种提取物成分(醇提物和水提物)对老年痴呆大鼠的治疗和改善作用.结果与结论:两种提取物成分均能在不同程度上改善老年痴呆模型大鼠的学习记忆功能,该作用与其增强总超氧化物歧化酶(SOD)活性,同时抑制谷胱甘肽过氧化物酶GSH-PX及脂质过氧化物丙二醛(MDA)的生成密切相关.%Waternut Herb, the overground stem of eleocharis dulci, has not been known for its effect on the nerve degenerative diseases at present. Our previous results show that the extracts of waternut herb own the powerful antioxidation which implied its potential in the prevention and therapy for nerve degenerative diseases. To test the hypothesis, this study is performed to explore the inhibitory effect of two extracts derived from waternut herb, alcohol and aqueous extracts on the Aβ - induced Alzheimer s disease ( AD) in rats. Our findings manifest that two extracts of waternut herb improve the capacities of study and memory in AD rats. The protective effect is involved in the reduction of glutathione peroxidase ( GSH — PX) activity and lipid peroxida-tion production of malondialdehyde (MDA)as well as the induction of total superoxide dismutase (T - SOD) activity. These results will provide the novel clues for exploiting drugs against AD from plants.