泮托拉唑联合硫糖铝对老年颅脑损伤并发应激性溃疡患者血清SOD、GAS及胃黏膜pH值的影响

摘要

Objective To observe the effects of pantoprazole combined with sucralfate on serum levels of su-peroxide dismutase (SOD), gastrin (GAS) and the value of gastric intramucosal pH in elderly patients with craniocere-bral injury and secondary stress ulcer. Methods The drug group consisted of 36 elderly patients with craniocerebral injury combined with secondary stress ulcer, and the control group consisted of 36 elderly and healthy men. The levels of SOD, GAS and value of pH between two groups were compared and analyzed. Results The level of SOD and value of pH in drug group were increased compared with the control group (P<0.05), and the level of GAS was decreased (P<0.05). After treatment, compared with immediate admission, the levels of SOD and pH were both increased significantly increased (P<0.05), and the GAS activities were significantly decreased in drug group (P<0.05). Conclusion Pantopra-zole combined with sucralfate is effective for craniocerebral injury and secondary stress ulcer, and the mechanism might be related to improving the activity of SOD, decreasing the content of GAS and elevating the value of pH.%目的：观察泮托拉唑联合硫糖铝对老年颅脑损伤并发应激性溃疡患者血清超氧化物歧化酶(SOD)、胃泌素(GAS)及胃黏膜pH值的影响。方法选择36例老年颅脑损伤并发应激性溃疡患者作为给药组，同期36例经体检合格的老年人作为对照组，分别检测患者血清中SOD和GAS，测定患者胃黏膜pH值，并进行比较分析。结果给药组患者不同时间段血清中SOD水平、胃黏膜pH值明显低于对照组，而GAS水平明显高于对照组，差异均有统计学意义(P<0.05)；经托拉唑联合硫糖铝治疗后，给药组各时间点与同组内入院即刻相比，患者血清中SOD活性明显升高，GAS活性明显降低，胃黏膜pH值也显著升高，差异均有统计学意义(P<0.05)。结论泮托拉唑联合硫糖铝对老年颅脑损伤并发应激性溃疡具有良好的治疗作用，其机制可能与促进体内SOD活性的提高，抑制GAS活性，升高胃黏膜pH值有关。