细胞自噬与活性氧的关系

摘要

自噬在生命活动中扮演着重要角色,与许多疾病密切相关.活性氧作为多个信号通路中的信号分子,可参与自噬的启动,并对细胞产生有利或有害的影响.细菌侵袭细胞诱发自噬的过程中可产生活性氧,并有一定的杀菌作用.活性氧在天然免疫中的作用,有望成为预防、治疗感染性疾病新的抗菌物质.%Autophagy plays an important role in life, which is closely related to many diseases. Reactive oxy-gen species are small high reactive molecules and signal molecules in many signaling pathways, which take part in start of autophagy and exert negative or positive effects to cells. Reactive oxygen species could be produced by autophagy process induced by bacterial cell invasion, which have certain antimicrobial effects. The effects of reactive oxygen spe-cies in innate immunity would become new antimicrobial substances for preventing and treating infectious diseases.