P16及Ki67在恶性潜能未定子宫平滑肌肿瘤中的表达及临床意义

摘要

Objective To investigate the expression of P16 and Ki67 in STUMP and to evaluate its clinical significance. Methods The expression of P16 and Ki67 was detected by immunohistochemical SP method of in STUMP of 11 cases, LM of 29 cases and LMS of 16 cases. Results The positive rates of P16 and Ki67 were 63.6%and 8.9%in STUMP of 11 cases, 13.8%and 7.4%in LM of 29 cases, 93.8%and 41.6%in LMS of 16 cases. Conclusions The detection of P16 and Ki67 is valuable for the diagnosis and differential diagnosis in STUMP, even for forecasting the prognosis.%目的：检测P16及Ki67等抗体在恶性潜能未定的子宫平滑肌肿瘤（smooth muscle tumor of uncertain malignant potential，STUMP）中的表达，并探讨其临床意义。方法应用免疫组化S-P法检测子宫11例STUMP、29例平滑肌瘤（leiomyoma，LM）及16例平滑肌肉瘤（leiomyosarcom，LMS）中P16及Ki67表达情况。结果 P16在STUMP、LM和LMS的阳性率分别为63.6%（7/11）、13.8%（4/29）及93.8%（15/16），差异有统计学意义（P＜0.05）。STUMP中有2例P16呈弥漫强阳性表达，该2例均复发。Ki67阳性指数在STUMP、LM和LMS的平均数分别为8.9%、7.4%及41.6%，差异有统计学意义（P＜0.05）。11例STUMP及29例LM中Ki67阳性指数均不超过20%；16例LMS中Ki67阳性指数均＞20%，其中9例（56.3%）超过30%。结论 P16及Ki67有可能成为STUMP诊断、鉴别诊断与判断预后的有用指标。