FSHR基因Ala307Thr单核苷酸多态性与浆液性卵巢癌易感性的关联

摘要

目的 探讨FSHR基因第10外显子Ala307Thr单核苷酸多态性与浆液性卵巢癌易感性的关联.方法 采用病例对照研究方法,收集48例浆液性卵巢癌患者的卵巢组织和30例非妇科恶性肿瘤患者的外周血.采用PCR-RFLP技术对样本中的FSHR基因第10外显子Ala307Thr进行基因分型检测.结果 FSHR基因第10外显子Ala307Thr在浆液性卵巢癌患者组和对照组之间的基因型分布存在显著差异(P=0.000 4),经年龄调整后两组的307Ala携带率有显著性差异(P=0.001),OR值为6.525(95％CI=2.202～19.335).结论 FSHR基因第10外显子Ala307Thr与浆液性卵巢癌的发病风险相关,307Ala携带可能会增加浆液性卵巢癌的发病风险.%Objective To investigate the relationship between the SNP Ala307Thr in follicle stimulating hormone receptor (FSHR) exon 10 and the susceptibility of ovarian serous cancer. Methods In this case-control study,ovarian tissues were collected from 48 patients with ovarian serous cancer and peripheral blood samples from 30 women without gynecological malignant tumors as control. ByPCR-RFLP, genotyping analyses were performed on Ala307Thr in FSHR exon 10. Results ' The distribution of three genotypes of FSHR Ala307Thr ( Thr/Thr, Ala/Thr and Ala/Ala) was statistically different between the case and control groups ( P = 0. 000 4). And the rate of 307Ala carriers was significantly different in two the groups after age was adjusted (P = 0. 001 ,OR = 6. 525, 95%CI:2. 202 - 19. 335). Conclusions Ala307Thr in FSHR exon 10 correlated with the susceptibility of ovarian serous cancer. 307Ala carriers were associated with significantly increased the risk of development of ovarian serous cancer.