The current study was carried out to optimize the ultrasonic-microwave assisted extraction of chlorogenic acid from Flos Lonicerae. The extraction yield of chlorogenic acid was investigated with respect to temperature, ethanol concentration, solid-to-solvent ratio, microwave power and irradiation time. The combined use of ultrasonic and microwave provided higher extraction efficiency than their individuals. An extraction yield of chlorogenic acid of 5.93%was obtained when ultrasonication for 30 min followed by microwave irradiation at a power of 400 W for 5 min was used for the extraction of Flos Lonicerae with 70%ethanol at a solid-to-solvent ratio of 1:15 (g/mL).%对金银花绿原酸进行超声波和微波双辅助提取研究。以绿原酸提取率为考察对象,研究超声温度、乙醇体积分数、料液比、微波功率及辐射时间等因素对金银花绿原酸提取率的影响。结果表明:采用超声波和微波双辅助提取技术得到的绿原酸提取率较单独采用超声波或微波辅助得到的绿原酸提取率高。以体积分数70%乙醇溶液为溶剂、料液比1:15(g/mL)、50℃超声处理30min、微波功率400W、微波时间5min,得到的绿原酸提取率为5.93%。
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