外泌体在恶性肿瘤放疗中的研究进展

摘要

Exosomes are cell-derived vesicles and have biological activity.The diameter of exosomes is between 30 and 120 nm.Exosomes participate in the invasion,metastasis and multi-drug resistance of malignant tumors.In the field of radiotherapy,it has been proven that radiation-induced changes in the secretion of exosomes from tumor cells can affect intercellular communication and enhance the radiotherapy resistance of tumor cells.In this article,the research progress on exosomes in the radiotherapy for malignant tumors was reviewed.%外泌体是细胞分泌的直径在30～ 120 nm的具有生物学活性的盘状囊泡,参与恶性肿瘤的侵袭、转移及多药耐药等诸多方面.在放射治疗领域,目前已证实放射线所引起的肿瘤细胞外泌体分泌的变化,可影响细胞间的通讯作用,同时增加肿瘤细胞的放射线抗性.本文就外泌体在恶性肿瘤放疗中的研究进展作一综述.