多尼培南的新合成路线

摘要

Objective: To optimize the synthetic route of doripenem. Methods: Doripenem was synthesized by nine steps from (L) -4-hydroxyl proline using carbobenzoxy chloride (CbzCl) as the protective agent for its side chain. Results and Conclusion: The structure of doripenem has been verified by 'H-NMR, 13C-NMR and LC-MS. The procedure is cheap, simple and suitable for industry.%目的:改进多尼培南的制备工艺.方法:以(L)-4-羟基脯氨酸为起始原料,用苄氧羰基氯(CbzCl)做侧链保护试剂,通过9步反应制得多尼培南.结果与结论:目标产物结构经1H-NMR、13C-NMR和LC-MS确证.改进后的制备工艺路线操作简便,成本低,适宜工业化生产.