血清IL-18和IL-33对急性哮喘发作患者的检测价值

摘要

Objective:Through the changes of serum IL-18 and IL-33 levels after treatment in patients with acute asthma detection,analysis and Discussion on the correlation between IL-18 and IL-33 and pulmonary function and bronchial asthma,the effects of IL-18 and IL-33 in the diagnosis of bronchial asthma.Methods:150 cases of asthma in 2010 January-2012 year in December my courtyard Respiratory Department of internal medicine in our hospital with acute attack were randomly selected as the research object,physical examination center and 150 healthy persons as control group,the observation group patients in oral methylprednisolone 40~80mg/D,1~2 weeks after treatment,respectively,and the control group before and after treatment of detection of serum IL-18,IL-33 levels and immunoglobulin E (IgE),lung function and eosinophil (EOS),relative contrast were observed before and after treatment,IL-33 level changes of IL-18 and control group differences and with IgE,EOS index.Results:The observation group of patients before treatment the serum IL-18 and IL-33 levels were (307.3±171.1)pg/ml and (216.7±84.6)pg/ml were higher than those in the control group,significant difference (P<0.05);after treatment,serum IL-18 and IL-33 levels were (207.3±83.3)pg/ml and (151.3±37.2)pg/ml were lower than that before treatment,significant difference (P<0.05),consistent with the IgE and EOS changes;observation of FEV1,FEV1%Ppre,FEV1/FVC,and the patients in the treatment group after treatment compared to the previous level ratio are increased,significant difference (P<0.05);observation group were IL-18,1L-33,lgE,EOS,high sensitive C reactive protein (hs-CRP).There was a positive correlation between the (P<0.05),negative associated with FEVl%,FEV1/FVC (P<0.05).Conclusion:lL-18 and IL-33 and acute asthmatic attacks,and abnormal lung function was associated with,is a reflection of an important index for the diagnosis of different stages and different severity of asthma.%目的：通过检测急性哮喘患者治疗前后血清IL-18和IL-33水平的变化,探讨分析IL-18和IL-33与肺功能水平以及支气管哮喘之间的相关性,研究IL-18和IL-33在支气管哮喘临床诊断中的作用。方法：选择2010年1月~2012年12月我院呼吸内科收治的150例哮喘急性发作患者为研究对象,随机抽取体检中心150例健康体检者作为对照组,观察组患者于口服甲泼尼龙40~80mg/d,治疗1~2周后,分别检测治疗前后及对照组血清IL-18、IL-33水平以及免疫球蛋白E(IgE)、肺功能及嗜酸粒细胞(EOS)等,对比观察组患者治疗前后IL-18、IL-33水平的变化及其与对照组之间的差异以及与IgE、EOS等指标的相关性。结果：观察组患者治疗前血清IL-18和IL-33水平分别为(307.3±171.1)pg/ml和(216.7±84.6)pg/ml均高于对照组,差异显著(P<0.05)；治疗后血清IL-18和IL-33水平分别为(207.3±83.3)pg/ml和(151.3±37.2)pg/ml均低于治疗前,差异显著(P<0.05),与IgE和EOS变化一致；观察组患者治疗后FEV1、FEV1%Ppre、FEV1/FVC等与治疗前相比水平比均升高,差异显著(P<0.05)；观察组患者IL-18、1L-33、lgE、EOS、超敏C反应蛋白(hs-CRP)之间呈正相关(P<0.05),与FEVl%、FEV1/FVC呈负相关(均P<0.05)。结论：lL-18和IL-33与哮喘急性发作有关,与肺功能异常具有相关性,是反映哮喘不同阶段及不同严重程度的一个重要诊断指标。