antibody or antigen-binding fragment thereof, humanized antibody, antigen-binding fragment, transformed or transfected recombinant host cell, methods of producing an antibody, for treating a human patient afflicted with a disease, to prevent acute asthmatic attacks in a human patient , and to reduce the frequency and / or mitigate the effects of acute asthmatic attacks on a human patient, pharmaceutical composition, kit of parts, and use of an antibody or antigen-binding fragment thereof.

摘要

ANTIBODY OR ITS ANTIGEN BINDING FRAGMENT, HUMANIZED ANTIBODY, ANTIGEN BINDING FRAGMENT, TRANSFORMED OR TRANSFORMED HOST STUDY, METHODS TO PRODUCE AN ANTANGULAR PATIENT TO A HUMAN PRESSURE , AND TO REDUCE THE FREQUENCY AND / OR MITIGUE THE EFFECTS OF ACUTE ASTHMATIC ATTACKS ON A HUMAN PATIENT, PHARMACEUTICAL COMPOSITION, PARTS KIT, AND USE OF ANTIBODY OR ANTIGEN CONNECTION FRAGMENT, particularly the present invention pertains to the present invention. antibodies specifically binding to human interleukin 13 (hIL-13). Antibodies of the invention may be used in the treatment of a variety of diseases or disorders responsive to modulating the interaction between hIL-13 and the human IL-13 receptor. Such diseases include severe asthma, atopic dermatitis, COPD and various fibrotic diseases. Pharmaceutical compositions comprising said antibodies and methods of manufacture are also presented.