humanized immunoglobulin light and heavy chains, humanized immunoglobulin, humanized antibody, chimeric immunoglobulin, pharmaceutical composition, isolated polypeptide, polypeptide variant, isolated nucleic acid molecule, vector, host cell, transgenic animal, variable region sequence use, kit for imaging, therapeutic composition, and methods for preventing or treating an amyloidogenic disease and alzheimer's disease in a patient, for producing an antibody or fragment thereof, for identifying substitutable residues, for imaging brain amyloid deposits of a patient, to reduce plaque burden in a subject, to reduce neuritically load in a subject, and to reduce amyloid beta peptide load and neuritically dystrophy in a mammal

摘要

"CHAINS LIGHT AND HEAVY humanized immunoglobulin, humanized immunoglobulin, antibody HUMANIZED, Chimeric Immunoglobulin, A pharmaceutical composition, isolated polypeptide, VARIANT A polypeptide, Molecule Nucleic Acid ISOLATED, VECTOR, host cell, transgenic animal, region sequence USE OF VARIABLE, IMAGE KIT, THERAPEUTIC COMPOSITION, AND METHODS FOR PREVENTING OR TREATING AMYLOIDOGENIC DISEASE AND ALZHEIMER IN A PATIENT, TO PRODUCE ANTIBODY OR FRAGMENT OF THE SAME, FOR IMMEDIATE FOR PASSES OF SUBSTITUES OF PASSITIES A PATIENT BRAIN, TO REDUCE PLATE LOAD IN A SUBJECT, TO REDUCE NEURIC LOAD IN A SUBJECT, AND TO REDUCE AMYLOID BETA PEPTIDE LOAD IN A MAMMFERO ". The invention provides improved agents and methods for treating diseases associated with Aβ amyloid deposits in the brain of a patient. Preferred agents include antibodies, for example, humanized antibodies.