贝前列素钠对老年2型糖尿病合并下肢血管病变患者血清TNF-α、sICAM-1的影响

摘要

Objective To observe the serum tumor necrosis factor-beraprost sodium on elderly patients with type 2 diabetic patients with lower extremity vascular disease alpha (TNF-α),soluble intercellular adhesion molecule-1 (sI-CAM-1)effect.Methods 160 cases of elderly patients with type 2 diabetic patients with lower extremity vascular dis-ease,divided into the control group (80 cases)and observation group (80 cases).Two groups were treated with routine drugs to control blood sugar.Control group:Aspirin Enteric-coated Tablets 75mg,oral,qd.The observation group:beraprost sodium,oral administration of 40μg,tid.ELISA was used to detect serum TNF-α,sICAM-1 before and after treatment.Results The control group before and after treatment the serum TNF-α,sICAM-1 had no significant change (P>0.05);and the observation group after treatment,serum TNF-α,sICAM-1 were significantly lower than those be-fore therapy and control group after treatment (P<0.05)level.Conclusion beraprost sodium has a better therapeutic effect on vascular disease in the lower limbs in aged patients with type 2 diabetes mellitus,expression can significantly decrease the serum TNF-α,sICAM-1 .%目的：观察贝前列素钠对老年2型糖尿病合并下肢血管病变患者血清肿瘤坏死因子-α（TNF-α）、可溶性细胞间粘附分子-1（sICAM-1）的影响。方法选择老年2型糖尿病合并下肢血管病变患者160例，分为对照组（80例）和观察组（80例）。两组均给予常规药物控制血糖。对照组：阿司匹林肠溶片75 mg，口服，qd。观察组：贝前列素钠，40μg，口服，tid；6个月。采用 ELISA法检测用药前后血清 TNF-α、sICAM-1。结果对照组用药前后血清 TNF-α、sICAM-1无明显变化（P＞0．05）；而观察组用药后血清 TNF-α、sICAM-1均明显低于用药前及对照组用药后水平（P＜0．05）。结论贝前列素钠能明显降低老年2型糖尿病合并下肢血管病变患者血清TNF-α、sICAM-1的表达。