Objective To explore the relation of serum transforming growth factorβ1(TGF-β1),interleukin-17A(IL-17A)levels and lung function in patients with coal worker’s pneumoconiosis (CWP).Methods Methods The levels of serum TGF-β1 and IL-17A were determined in 118 CWP patients (CWP group),61 miners (dust exposed control group)and 53 healthy controls by sandwich ELISA;the forced vital capacity (FVC%),forced expiratory volume in one second (FEV1%),(FEV1/FVC%)and maximal mid-expiratory flow (MMEF75/25%)were determined by special lung function machine.Results Compared with healthy control group,the levels of TGF-β1 and IL-17A were signifi-cantly higher in CWP (P <0.05,P <0.01),IL-17A in CWP were significantly higher than that of dust exposed control group (P <0.01).Four parameters of lung function in CWP were lower distinctly than that of dust exposed control group(P <0.05,P <0.01).TGF-β1 levels were significantly lower in CWP with chronic obstructive pulmonary disease than that of simple CWP(P<0.01).In CWP,TGF-β1 were negatively correlated with FEV1/FVC(%)(r=-0.427,P<0.05).Conclusion The levels of serum TGF-β1 in CWP may be related to disease severity,and reflect the lung func-tion indirectly;the detection of seurm IL-17A levels may be valuable for diagnosis of CWP;TGF-β1 and IL-17A may play a role respectively in the occurrence and development of CWP.%目的：探讨血清转化生长因子β1（TGF-β1）和白细胞介素-17A（IL-17A）水平在煤工尘肺（CWP）中的变化及其与肺功能关系。方法采用双抗体夹心 ELISA 法检测118例 CWP 患者（CWP 组）、61例具有与 CWP 组相同接尘条件的健康井下接尘矿工（接尘对照组）及53例井上健康查体人员（正常对照组）血清 TGF-β1和 IL-17A 水平；用肺功能机检测用力肺活量（FVC％）、一秒钟用力呼气量（FEV1％）、用力呼气1秒率（FEV1/FVC％）、最大呼气中期流速（MMEF75/25％）4项肺功能指标。结果与正常对照组比较，CWP 组 TGF-β1和 IL-17A 水平明显升高，差异具有统计学意义（P ＜0．05和 P ＜0．01）；CWP 组 IL-17A 水平明显高于接尘对照组（P ＜0．01），而4项肺功能指标均明显降低，差异具有统计学意义（P ＜0．05和 P ＜0．01）。CWP 并发慢性阻塞性肺疾病组 TGF-β1水平明显低于单纯CWP 组（P ＜0．01）。CWP 组 TGF-β1与 FEV1/FVC（％）呈负相关（r ＝-0．427，P ＜0．05）。结论CWP 患者血清TGF-β1水平可能与疾病严重程度有关，并间接反映肺功能；检测 IL-17A 水平可能对协助诊断 CWP 有一定参考价值；TGF-β1和 IL-17A 在 CWP 发生发展中可能各自发挥其作用。
展开▼
