磁共振动态增强定量分析对前列腺疾病的诊断价值

摘要

目的 探讨磁共振动态增强检查(DCE-MRI)定量参数对前列腺良恶性疾病的鉴别诊断价值. 方法 回顾性收集2012年6月至2013年3月期间接受DCE-MRI检查并经病理证实的前列腺癌患者12例及前列腺良性增生患者16例,在癌区、非癌区外周带和非癌区中央带分别放置感兴趣区(ROI),得到相应各区的定量分析参数Ktrans(转运常数)、Kep(速率常数)及Ve(血管外细胞外间隙体积百分数),利用单因素方差分析比较三组间各参数值有无差异. 结果 癌区的Ktrans、Kep、Ve值分别为(0.42士0.10)/min、(0.64±0.11)/min、0.61±0.14;非癌区外周带分别为(0.17±0.08)/min、(0.32±0.10)/min、0.59士0.11;非癌区中央带分别为(0.33±0.12)/min、(0.50±0.16)/min、0.62±0.07.三组的Ktrans、Kep值差异有统计学意义(F分别=31.546、27.196,均P＜0.05),而Ve值差异无统计学意义(F=0.533,P＞0.05). 结论 DCE-MRI定量分析可用于前列腺良恶性疾病的鉴别,具有很大应用前景.%Objective To evaluate the diagnostic value of quantitative analysis parameters of dynamic contrast-enhanced magnetic resonance imaging (MRI) in differential diagnosis of prostatic disease.Methods 12 patients with prostate cancer and 16 patients with benign disease underwent DCE-MRI examination.Region of interest (ROI) were drawn in areas of cancerous foci,normal prostate peripheral zone and normal prostate central gland to measure the values of Ktrans (transport constant),Kep (rate constant),Ve (extravascular extracellular volume fraction).Values of the three parameters were analyzed by ANOVA and the differences were compared between the different tissues.Results The values of Ktrans,Kep and Ve were (0.42±0.10)/min,(0.64±0.11)/min,(0.61±0.14) respectively in the area of cancerous foci,while (0.17 ±0.08)/min,(0.32 ±0.10)/min,(0.59±0.11) respectively in normal prostate peripheral zone,and (0.33±0.12)/min,(0.50± 0.16)/min,(0.62 ±0.07) respectively in normal prostate central gland.The differences in Ktrans,Kep values were statistically significant between cancerous foci,normal prostate peripheral zone and normal prostate central gland (F =31.646,27.196,respectively,all P ＜ 0.05),but no statistically significant difference was found in the Ve value between the three different tissues (F=0.533,P＞ 0.05).Conclusions Quantitative analysis of DCE-MBI can be used to differentiate benign from malignant prostatic diseases,which hasa great application prospect.