3．0T动态增强磁共振对前列腺癌的定量分析研究

摘要

Objective:To study the diagnostic value of quantitative analysis parameters of DCE-MRI in the diagnosis of prostate cancer and to evaluate the correlation between Ktrans and Gleason scores.Methods:Forty patients with pathologi-cally proved prostate diseases underwent conventional MRI and DCE-MR examinations.They were divided into three groups:cancerous foci,noncancerous area in the peripheral zone and central gland.ROIs were drawn on areas of prostate tis-sue to measure the values of Ktrans ,Ve and Kep .The 3 parameters in the different groups were analyzed,and the correlations between Ktrans and Gleason scores were studied.Results:The Ktrans ,Ve and Kep valuesof cancerous foci were (0.62±0.10)/min, (0.44±0.12)and (1.45±0.25)/min,respectively,while,for noncancerous area in the peripheral zone were (0.21± 0.06)/min,(0.29±0.65),(0.76±0.21)/min,respectively,and for noncancerous area in the central gland were (0.32± 0.09)/min,(0.34±0.70),(0.95±0.26)/min,respectively.The differences between Ktrans,Ve and Kep values of the three groups were statistically significant (F= 234.338,32.593 and 92.462,respectively;P<0.05).Significant correlation was found between Ktrans and Gleason score (r= 0.533,P<0.05).Conclusion:The differences of Ktrans,Ve and Kep among the three groups (cancerous foci,noncancerous area in the peripheral zone and central gland)are statistically significant.3 .0T DCE-MRI quantitative analysis plays an important role in the diagnosis of prostate cancer.Positive correlation is found be-tween Ktrans and Gleason score.Ktrans can be used for evaluating the degree of malignancy of prostate cancer.%目的：探讨3．0T磁共振动态增强（DCE-MRI）定量分析对前列腺癌的诊断价值，并评价Ktrans与 Gleason 评分的相关性。方法：回顾性分析40例经病理证实的前列腺疾病患者的病例资料，其中前列腺癌（PC）患者28例，前列腺增生（BPH）患者12例，每例患者均行常规 MRI 和 DCE-MRI 检查，通过与病理结果对照，在 MRI 图像上共选取130个样本，分为前列腺癌区、外周带非癌区和中央腺体非癌区三组，在前列腺定量参数伪彩图上取 ROI 并测量Ktrans、Ve 及Kep值，对三组的各参数值分别行方差分析，并检验PC组Ktrans值与Gleason评分的相关性。结果：前列腺癌区的Ktrans、Ve 及Kep值分别为（0．62±0．10）min-1、（0．44±0．12）和（1．45±0．25）min-1，外周带非癌区分别为（0．21±0．06）min-1、（0．29±0．65）和（0．76±0．21）min-1，中央区非癌区分别为（0．32±0．09）min-1、（0．34±0．70）和（0．95±0．26）min-1， Ktrans、Ve 及Kep值在各组间差异均有统计学意义（F值分别为234．338、32．593及92．462，P 值均＜0．05）；PC组Ktrans、Ve值在不同Gleason评分组间差异有统计学意义（F值分别为6．354、9．217，P值均＜0．05），Kep值在不同Gleason评分组间差异无统计学意义（P值＞0．05）；前列腺癌区的Ktrans值与Gleason评分呈正相关（r＝0．533，P＜0．05）。结论：3．0T DCE-MRI定量分析研究能为PC的诊断提供客观依据。前列腺癌区的Ktrans值与Gleason评分呈正相关，提示定量参数Ktrans值可用于评估PC的恶性程度。