Ⅰ型糖尿病胰岛移植术后代谢特征的观察和分析

摘要

目的 探讨Ⅰ型糖尿病患者胚胎胰岛移植术后代谢状况与移植物的功能及存活的关系。方法 将培养后的胎儿胰岛细胞移植至26例Ⅰ型糖尿病患者的大网膜及小网膜腔内，比较患者的各项代谢指标与移植效果之间的关系。结果 本组术后胰岛素用量均有明显减少（P<0.05），血清C肽及胰岛素水平升高。术后13例患者空腹血清C肽≥0.5ng/ml，9例≥0.5ng/ml持续超过1年。结论 胰岛移植是治疗Ⅰ型糖尿病的有效方法。%Objective To assess the effect of fetal islet t ransplantationfor the treatment of Type Ⅰ diabetes. Methods The pancreatic islets from human aborted embryos we re cultured and implanted into the greater omentum and omental bursa of 26 patie nts with type Ⅰ diabetes. The function of transplanted islets was evaluated.[ KG2 Results After transplantation, the exogenous insulin requirement significantly decreased (P<0.05). The fast s erum C-peptide level was ≥ 0.5ng/ml in 13 transplanted patients, and ≥ 0. 5 ng/ml in 9 cases for more than one year, among them one case has been on norm al level for 14 years. Conclusion Islet transplantation is an effective way for the treatment of type Ⅰ diabetes.