insulin derivative, intermediate product, use of an insulin derivative, and, methods for the treatment or prevention of diabetes, type 1 diabetes, type 2 diabetes, impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity, metabolic syndrome, hypertension , cognitive disorders, atherosclerosis, myocardial infarction, stroke, cardiovascular disorders, coronary heart disease, inflammatory bowel syndrome, dyspepsia, hypotension or gastric ulcers, and to determine the selectivity of an insulin compound

摘要

the present invention relates to new insulin analogs and their derivatives, such as acylated insulin analogs and their pharmaceutical use, in particular, in the treatment or prevention of medical conditions related to diabetes, obesity and cardiovascular diseases.