The effect of whole egg on DNA hypomethylation and disruption of one-carbon metabolism in insulin dependent diabetes mellitus.

摘要

Diabetes mellitus is linked with a higher risk of cardiovascular disease and certain types of cancer [61-63]. A study of Type 1 and Type 2 diabetics in Australia showed multi-fold increases in the risk for several types of cancer. Diabetics are also two to four times more likely to have CVD than an adult without diabetes. The common thread among these three medical conditions is oxidative stress. To date, little work has been done on the impact of dietary intervention on the body's ability to handle the increased oxidative stress caused by diabetes. In this study, male Sprague-Dawley rats were fed a high choline diet for 4 weeks (3 weeks acclimation and 1 week experimental). Diabetes was induced using STZ and after 1 week the rats were sacrificed and liver tissue was harvested for study. There was a significant decrease in GNMT abundance between the non-diabetic control and whole egg diet groups, but not between the diabetic control group and whole egg diet group. There was no attenuation of hepatic hypomethylation in the group fed the high choline diet in comparison to the diabetic control group (P = .121). No significant difference was seen in serum TG levels between groups (P = 0.462).