文拉法辛治疗抑郁症伴焦虑症状患者的临床疗效分析

摘要

目的：探究文拉法辛在治疗抑郁症伴焦虑症状患者中的应用。方法回顾性分析2011年1月至2012年1月于本院接受治疗的抑郁症伴焦虑症状患者106例，随机分为两组，每组各53例。对照组口服氟西汀（20～40 mg/d），研究组口服文拉法辛（75～225 mg/d），疗程均为8周。分别于治疗前以及治疗后2、4、8周采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）对疗效进行评价，并采用不良反应量表（TESS）判定不良反应发生情况。结果研究组总有效率为75.00%，高于对照组（58.00%），HAMD、HAMA得分明显低于对照组，差异均具有显著性（P均＜0.05）。研究组患者不良反应发生率低于对照组，差异具有显著性（P＜0.05）。结论文拉法辛对抑郁症伴焦虑症状的疗效确切，不良反应较少，起效快于氟西汀，适宜临床推广。%Objective To study the clinical effect of treating depression with anxiety disorder using venlafaxine. Method Chose 106 patients from January 2011 to January 2012, divided into study group and control group. Patients in control group were treated with lfuoxetine (20~40 mg/d), and the study group were treated with venlafaxine (75~225 mg/d). The course of treatment was 8 weeks. Using HAMD and HAMA to evaluate the treatment effects, and using TESS to judge adverse reactions. Result The total effective rate of study group was signiifcantly higher than control group (P<0.05). The score of HAMD and HAMA in study group was signiifcantly better than control group (P<0.05). The adverse reactions of study group was less than control group (P < 0.05). Conclusion Compared with lfuoxetine, treating depression with anxiety disorder using venlafaxine is effective to improve the treatment effect and worth to extend in clinic.