Method for predicting therapeutic response to vasopressin receptor 1B antagonist in patients having at least one of depressive symptoms and anxiety symptoms

摘要

The present invention relates to a method for predicting a treatment response to a corticotropin releasing hormone receptor type 1 (CRHR1) antagonist and/or a vasopressin receptor 1B (Vsub1B/sub) antagonist in a patient with depressive and/or anxiety symptoms. The present invention furthermore relates to a Vsub1B/subreceptor antagonist and/or CRHR1 antagonist for use in the treatment of depressive symptoms and/or anxiety symptoms in a patient. Also, kits, diagnostic compositions, devices and microarrays allowing the determination of the presence or absence of at least one polymorphic variant in the AVPR1B gene in combination with the presence or absence of at least one polymorphic variant in the patient's genome excluding the AVPR1B gene in the nucleic acid sample are described.