细菌对抗菌肽的抗性及机理

摘要

抗菌肽(AMPs)是一类广泛存在于自然界生物体中的小肽类物质,它是机体先天性免疫系统的重要组成部分.AMPs作为传统抗生素的替代品被广泛重视,然而细菌对于AMPs的抗性如同对抗生素的耐药性一样不容忽视.本文主要从浮游菌、生物膜和信号调节3个方面阐述细菌对于AMPs的抗性及机理.%Antimicrobial peptides (AMPs), are a class of small peptides that widely exist in many creatures in nature, and they are essential components of the innate immune system.AMPs, as a potential alternative to the traditional antibiotics, gain more extensive attention;however, the resistance of bacteria to AMPs as well as to antibiotics should not be ignored.This review summarized the resistance of bacteria to AMPs and it's mechanism from three aspects of planktonic bacteria, biofilm and signal regulatory.