Objective To evaluate the accuracy of the index of consciousness (IoC) in monitoring the depth of anesthesia with sevoflurane inhalation in children,by comparing it with the bispectral index (BIS).Methods Forty-two ASA physical status Ⅰ or Ⅱ children,aged 8-12 yr,scheduled for elective abdominal surgery under general anesthesia,were studied.Anesthesia was induced with sevoflurane inhalation.The patients were endotracheally intubated.The concentration of sevoflurane was then adjusted to maintain the end-tidal concentration of sevoflurane (CETSev) at 1.6%,2.1%,2.6%,3.1%,3.6%,4.1% and 4.6% for5 min.The IoC and BIS values were recorded simultaneously.Results When CETSev < 3.1%,CETSev was negatively correlated with IoC and BIS values,and the correlation coefficients between CETSev and IoC and BIS values were-0.927 (r1) and -0.869 (r2),respectively (P < 0.01).When 3.1% ≤ CETSev ≤ 4.6 %,CET Sev was negatively correlated with IoC and BIS values,and the correlation coefficients between CETSev and IoC and BIS values were-0.808 (r3,P< 0.01) and-0.430 (r4,P < 0.05),respectively.Comparison of the absolute value of correlation coefficients:there was no significant difference between r1,r2 and r3 (P > 0.05) ; r1,r2 and r3 were significantly larger than r4 (P < 0.01).Conclusion IoC can accurately reflect the depth of anesthesia with sevoflurane inhalation in children and when 3.1% ≤ CET Sev ≤ 4.6 %,the accuracy of IoC in monitoring the depth of anesthesia is superior to that of BIS.%目的 评价意识指数(IoC)监测小儿吸入七氟醚麻醉深度的准确性.方法 择期全麻下行腹部手术患儿42例,ASA分级Ⅰ级或Ⅱ级,性别不限,年龄8~ 12岁.吸入七氟醚麻醉诱导气管插管后,调节吸入七氟醚的浓度,分别维持呼气末七氟醚浓度(CET Sev) 1.6%、2.1%、2.6%、3.1%、3.6%、4.1%和4.6%5 min,同步记录IoC值和BIS值.结果 CET Sev< 3.1%时,其与IoC值、BIS值均呈负相关,相关系数分别为-0.927(r1)、-0.869 (r2)(P< 0.01);CETSev 3.1% ~ 4.6%时,其与IoC值、BIS值均呈负相关,相关系数分别-0.808(r3,P<0.01)、-0.430 (r4,P<0.05).相关系数绝对值比较:r1、r2及r3间比较差异无统计学意义(P>0.05),r1、r2、r3均大于r4(P <0.01).结论 IoC能准确反映小儿吸入七氟醚的麻醉深度;CETSev 3.1% ~ 4.6%时,IoC监测其麻醉深度的准确性优于BIS.
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