Comparison of Intravenous Propofol Using Target-Controlled Infusion and Inhalational Sevoflurane Anesthesia in Pediatric Patients

摘要

Propofol is used for the hypnotic effect and is characterized by a short onset of action and a prompt recovery from anesthesia. The target-controlled infusion system can administer drugs to patients more precisely and consistently. Sevoflurane is a popular inhalational anesthetic for general anesthesia in children. We conducted this study to compare the intravenous propofol using TCI system and inhalational sevoflurane anesthesia in pediatric patients. We collected clinical data of 128 pediatric patients who were underwent surgery from February, 2011 to February 2013 in the First Hospital of Jilin University. Patients were randomly assigned into two groups of either propofol TCI (group P, n = 64) and sevoflurane (group S, n = 64) using a computer generated randomization list. All patients were monitored with an electrocardiogram (ECG), non-invasive blood pressure (BP) and pulse oxygen saturation (SPO2). Patients in group P received an intravenous propofol infusion using a TCI system. Patients in group S received inhalational sevoflurane anesthesia. There was a significant difference between the two groups in hemodynamic variables after anesthesia and intubation and the group P decreased greater than group S (P ＜ 0.05). There was significant difference in the time of loss of consciousness, intubation, recovery of spontaneous respiration, and the cases of respiration depression between two groups (P ＜ 0.05). The time of loss of consciousness and intubation was longer in the group S than the group P (P ＜ 0.05). But the time of recovery of spontaneous respiration and consciousness was shorter in group S (P ＜ 0.05). There was less cases of respiration depression in group S (P ＜ 0.05). Both of the groups can provide satisfied anesthesia and have their own advantages and disadvantages. We should make good use of the doses of the infusion or inhalation of anesthetic drugs.