目的：观察丁苯酞对急性缺血性脑卒中患者循环内皮祖细胞水平的影响。方法选取首次发作48 h内的急性缺血性脑卒中患者96例，按就诊时间随机分为对照组和观察组，各48例。对照组患者静脉滴注银杏叶提取物注射液（20 mL/d）、口服阿司匹林肠溶片（100 mg/d）治疗，观察组患者在对照组治疗基础上给予丁苯酞软胶囊（200 mg，每日1次）口服治疗。两组患者均以4周为1个疗程，治疗3个疗程。记录两组患者治疗前后美国国立卫生院脑卒中量表评分（NIHSS），以评价临床疗效，检测外周血内皮祖细胞（EPCs）数量及迁移能力、血脂水平，定期检查血常规、肝肾功能，并记录治疗过程中不良反应的发生情况。结果观察组总有效率为89.58%，显著高于对照组的75.00%（ P0.05)。结论加用丁苯酞治疗急性缺血性脑卒中的临床疗效好，能有效改善患者的神经功能损伤，增加EPCs数量，增强其向损伤区域的迁移能力，帮助调节血脂，不良反应少，值得临床推广。%Objective To observe the effect of butylphthalide on circulating endothelial progenitor cells in patients with acute ischemia stroke. Methods 96 patients in the hospital diagnosed as acute ischemia stroke in 48 h were randomly divided into the treatment group and the control group,48 cases in each group. The control group was treated with extract of Ginkgo Biloba Injection(20 mL/d) and aspirin enteric tablets (100 mg/d);on this basis,the treatment group was added with butylphthalide(200 mg,qd). 4 weeks was 1 course of treatment,and the medication lasted for 3 courses. The NIHSS scores in each group were detected and recorded for the clini-cal efficacy,the amounts and the transfer ability of EPCs in peripheral blood were detected by flow cytometry,the TC,TG,LDL-C, HDL-C level in peripheral blood were observed,and the adverse reactions during treatment were recorded. Results The total effective rate of the treatment group was 89. 58%,which was significantly higher than 75. 00% of the control group( P 0. 05 ) . Conclusion Butylphthalide can improve the nerve function deficit in patients with acute ischemia stroke effectively,increase the amounts of EPCs,improve the transfer ability of EPCs,inhibit the brain mi-crocirculation thrombosis,with distinct clinical efficacy and fewer adverse reactions,which is worthy of clinical promotion.
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