三阴性乳腺癌放射治疗相关机制的研究进展

摘要

Radiotherapy is one of the main means of local treatment of breast cancer. Triple negative breast cancer (TNBC) as a molecular subtypes of breast cancer, its biological behavior is special and existing multiple molecular targets, these molecular targets inlfuence the response of ionization radiation through different mechanisms and regulate radiotherapy sensitivity of TNBC This article reviewed the recent advances in radiotherapy and radiosensitivity related molecular targets of TNBC.%放射治疗是乳腺癌局部治疗的主要手段之一。三阴性乳腺癌(triple-negative breast cancer，TNBC)作为乳腺癌分子亚型的一个分型，其分子及生物学行为具有多方面特殊性，并存在多个分子靶点的异常，这些异常分子靶点可通过不同机制影响肿瘤对电离辐射的反应，从而调节三阴性乳腺癌的放疗敏感性。现就TNBC的放射治疗及其放疗敏感性相关分子靶点的研究新进展予以综述。