目的 评价和比较服用标准剂量普伐他汀、辛伐他汀、洛伐他汀、阿托伐他汀、氟伐他汀后的冠心病罪犯血管内斑块负荷改变.方法 随机入选2006年3月6日至2007年3月6日收治的、进入意向治疗及安全性分析的非经皮冠状动脉介入术治疗、具有心绞痛症状的患者45例,完成研究者32例.采用随机、开放、交叉的对照研究,患者被随机指定到5个药物治疗序列中的任何一个.研究药物20 mg 1次/d睡前服用,每种药物各服用6个月.每个治疗药物周期间隔至少10 d的洗脱期.应用血管内超声(IVUS)技术对罪犯血管内斑块负荷进行定量分析.结果 阿托伐他汀治疗6个月后患者罪犯血管内斑块负荷减少百分比明显高于氟伐他汀、洛伐他汀、辛伐他汀、普伐他汀治疗后[(0.84±0.05)％比(0.44 ±0.22)％、(0.52±0.03)％、(0.39±0.07)％、(0.56±0.05)％,P＜0.01],心绞痛发作频率较基线时减少的次数明显多于氟伐他汀、洛伐他汀、辛伐他汀、普伐他汀治疗后[(13.4±1.1)次/周比(10.7±1.1)、(10.4±1.1)、(9.1±0.3)、(10.0±1.2)次/周,P＜0.01].结论 对于有心绞痛症状的患者,每日20 mg标准剂量的阿托伐他汀比标准剂量的普伐他汀、辛伐他汀、洛伐他汀和氟伐他汀能够更加有效地将罪犯血管内斑块控制在稳态,从而有效减少心绞痛的发生.%Objective To evaluate the effects ofpravastatin,simvastatin,atorvastatin,lovastatin,fluvastatin on criminals endovascular plaques of patients with coronary artery disease (CHD).Methods Thirty-two CHD patients were randomly assigned to anyone of 5 medications sequences,respectively acceped pravastatin,simvastatin,atorvastatin,lovastatin,fluvastatin for 6 months,criminals endovascular endovascular plaques were quantitative analyzed by intravascular ultrasound (IVUS) technology during each drug treatment cycle.Results Plaque load change percentage reduced respectively,and the difference between atorvastatin and fluvastatin,lovastatin,simvastatin,pravastatin was statistical significant [(0.84 ± 0.05) ％ vs (0.44 ± 0.22) ％,(0.52 ± 0.03) ％,(0.39 ±0.07) ％,(0.56 ± 0.05) ％,P ＜ 0.01].Accordingly,incidence of angina of patients after treatment with atorvastatin administration reduced from (17.5 ± 1.5)times/week to (4.1 ± 0.4)times/week and was significantly more than other administration drugs [fluvastatin,lovastatin,simvastatin,pravastatin group was (10.7 ± 1.1),(10.4 ±1.1),(9.1 ± 0.3),(10.0 ± 1.2) times/week,respectively,P ＜ 0.01].Conclusion Standard doses of atorvastatin(20 mg daily) can more effectively stabilize criminals endovascular plaques than pravastatin,simvastatin,lovastatin,fluvastatin in patients with angina,thus it can effectively reduce the incidence of angina.
展开▼
