比卡鲁胺的合成工艺改进

摘要

以甲基丙烯酰氯为原料,经N-酰化、环氧化、缩合和氧化合成了比卡鲁胺,总收率为57.6%,纯度为98.3%,并通过1HNMR、MS对其结构进行了确认.%Using methacryloyl chloride as a raw material,bicalutamide with the overall yield of 57.6% and the purity of 98.3% was synthesized by a four-step reaction of N-acylation,epoxidation,condensation and oxidation.The structure of bicalutamide prepared was confirmed by 1HNMR and MS.