鹅掌楸树脂醇A二甲醚是一种双四氢呋喃型木脂素类天然化合物，首次采用X射线衍射技术解析该化合物的单晶结构，确定其绝对构型。晶体数据显示分子式为C24 H30 O8，相对分子量446.48，属单斜晶系，C2／y空间群，Z＝4；晶胞参数a＝30.7519（6），b＝5.01824（12），c＝14.5251（3）？，V＝2237.74（8）？3，Dx＝1.325 g／m－3；经最小二乘法修正，最终偏离因子R＝0.0414，wR（F2）＝0.1034。基于该晶体Flack常数为0.02（9），确定其四个手性碳的绝对构型分别是10S，12R，13R和15R。同时，讨论了晶体中的π-π堆积作用。此外，测试了鹅掌楸树脂醇A二甲醚对五种细菌的抑菌活性，结果显示其对大肠杆菌的抵制活性最强，其最小抵制浓度低至2.5μg／mL。%The title compound of Epiyangambin,a furofuran lignan with bioactivity,was obtained from the stems of Polyalthia rumphii,and characterized by X-ray diffraction analysis. It crystallizes in monoclinic system,space group C2/y with C24 H30 O8 ,a=30. 7519(6),b=5. 01824(12),c=14. 5251(3)?,V=2237. 74(8)?3,Z=4,Dx=1. 325 g/m-3,Mr=446. 48,F(000)=952,andμ=0. 824 mm-1. The final factors were R=0. 040 and wR(F2)=0. 105 for 3931 independent reflections(Rint=0. 038),which were used in all calculations. The crystal structure of epiyangambin shows that the absolute configuration of those four chiral centers were 10S,12R,13R and 15R,which was unambiguously determined by refining the Flack parameter of 0. 02(9). Meanwhile,weak π-πstacking interactions was found. In addition,the preliminary antibacterial activities of Epiyangambin were evaluated against five bac-teria,and the results showed that this compound was with the significant minimal inhibitory concentrations(MICs)to parts of tested bacteria.
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