依据应答指导策略治疗慢性丙型肝炎复发后再治疗的3例病例分析

摘要

目的：分析慢性丙型肝炎复发的相关因素及罗氏试剂在慢性丙型肝炎初治与复发后再治疗中的指导意义。方法回顾性分析安徽医科大学第一附属医院感染科收治的3例依据应答指导治疗（RGT）策略治疗复发后再治疗患者的临床资料。结果3例患者初次治疗均复发而再治疗无1例复发。结论依据 RGT 策略治疗慢性丙型肝炎过程中，在0、4、12、24周时运用高灵敏方法检测丙肝病毒-RNA 定量（HCV-RNA），对疗效的判定以及防止治疗后复发可起到关键作用。%Objective To analyze the relative factors of relapse in patients of chronic hepatitis C and the clinical significance of Roche Cobas detection in the initial treatment and recurrence after relapse of chronic hepatitis C.Methods We retrospectively analyzed the clinical data of 3 cases of patients treated as patients of treatment after relapse based on RGT strategy and admitted to the Department of Infectious Diseases in the First Affiliated Hospital of Anhui Medical University.Results Patients of the three cases all relapsed after the initial treatment,but none of them relapsed after recurrence.Conclusions During the treatment of chronic hepatitis C based on RGT strategy,high-sensitive method should be applied to detect HCV-RNA respectively at 0,4,12 and 24 week,which plays a key role in judging the curative effect and preventing relapse after treatment.