TEMPERATURE RESPONSIVE COATING OF POROUS SILICON NANOPARTICLES FOR LOCAL HEAT-INDUCED RELEASE OF ANTICANCER DRUGS

摘要

We developed a novel drug nanocarricr based on mesoporous silicon coated with temperature responsive polymer, which can release a drug loaded in the pores just after the critical temperature has been exceeded. The polymer coating with a modified N-isopropylacrylamide (PNIPAm) was performed by atom transfer radical polymerization after the surface modification with the reaction initiator. Silicon nanoparticles can be heated efficiently with infrared or radiofrequency electromagnetic radiation, both resulting in the collapse of polymer chains, pore openings and trigging of the drug release.