设计了一种新型药物载体用以提高紫杉醇载体的稳定性和体外药物缓释性能.首先合成一种新型有机/无机复合脂质,采用薄膜水化法制备空白硅质体,并研究其稳定性；将其装载抗癌药物紫杉醇后,形成紫杉醇硅质体并研究体外药物缓释性能.结果表明:利用新型复合脂质制备的硅质体在表面活性剂环境中具有良好的稳定性；成功将紫杉醇包埋于硅质体中制备成紫杉醇硅质体,粒径大小为(170.5±2.9) nm,体外药物释放实验表明,它比传统紫杉醇脂质体具有更好的药物缓释性能,药物包封率达到(69.70±5.17)％,因此新型复合脂质制备的硅质体是一种理想的纳米药物载体材料.%To design a novel drug carrier in order to improve carrier stability and drug release capacity in vitro. A nanohybrid cerasome was fabricated from a new hybrid lipid by the Bangham method and its stability was studied by surfactant dissolution experiments. Paclitaxel - loaded cerasome was prepared and the drug release behavior was investigated in vitro by a dialytic method. The results suggest that compared to traditional liposome, novel cerasome exhibited remarkable stability in the presence of surfactant. Paclitaxel was successfully loaded into cerasome, and diameter as well as drug encapsulation efficiency of this drug - loaded nanoparticles were ( 170. 5 ± 2. 9 ) nm and (69. 70 ±5. 17) % respectively. Cerasome exhibited an excellent drug - controlled release performance. In conclusion new cerasome is a promising drug release carrier.
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