LOW ESTER AMIDATED CITRUS PECTIN AND FLAXSEED GUM AS SUITABLE CAREERS FOR WOUND HEALING AGENTS

摘要

Construction of novel more effective wound healing dresses is still actual task for medicine. Natural and modified polysaccharides are interesting as potential biodegradable non-toxic carriers for application of wound healing drugs. High and low ester pectins have recently been investigated for its use in various biomedical applications such as drug delivery, skin protection and cell immobilisation [1]. On the other hand, flaxseed gum was found to have antioxidant properties [2] and can be used as a career for silver nanoparticles for antimicrobial and wound-dressing applications [3]. Both pectin and flaxseed gum are interesting because of their moistening, smoothing, air permeability and other effects supporting wound healing. Gradual biodegradation of the polysaccharide matrix leads to a gradual release of the drug from the hydrogel carrier and thus can promote tissue regeneration without additional stress. In addition, these polysaccharides contain free carboxylic groups that can interact with cationic peptides, which were used as appropriate therapeutic agents. Some of these agents are insoluble in water and thus an oppositely charged polysaccharide may uptake them and uniformly distribute them in the bulk gel.