Dynamic of Thrombin Generation in Patients with Severe Hemophilia A

摘要

In hemophilia A, determination of factor VIII activity is used to classify the extent of impaired hemostasis and to estimate bleeding risks of patients. In contrast, the now established assays of thrombin generation (TGA) (1,2) are not based on a single clotting factor, but are reflecting the action of the total clotting mechanism. Especially in hemophilic patients, TGA offers the possibility to monitor the treatment with haemostatic agents.