Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A | Haematologica

摘要

Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better.