The mechanism of ultrasound-mediated transfection (USMT) was explored to get a better understanding and improvement of the efficiency. Efficiency of USMT was linked O cavitational effects and also to plasma membrane conditions. These results indicate that the mechanism underlying USMT is possibly explained by the interaction between the cavitational effect and a plasma membrane response. When both were combined, transfection efficiency was significantly enhanced in vitro and in vivo. This enhancement could be useful for ultrasound-mediated gene therapy in the future.
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