While it is generally accepted that selenium (Se) intakes of Australian and New Zealand consumers are sufficient to prevent overt signs of deficiency, the relatively low intakes of Se in these countries may contribute to an elevated risk of bowel cancer (Clark etal., 1996). As protein-bound Se is more bioactive and less toxic than other forms of Se, there is interest in increasing the amount of Se in animal proteins for human consumption. Since milk protein-bound Se is more bioavailable than inorganic Se and yeast-bound Se (Uglietta et ah, 2006), the aim of this study was to determine the effect of different forms of Se on the expression of selenoproteins gastrointestinal glutathione peroxidase (GI-GPX) and selenoprotein P (SelP) which may be involved in protection against colon cancer.
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