Particle detection systems and methods for on-axis particle detection and/or differential detection

摘要

Optical systems and methods for detecting and characterizing particles are provided herein. Systems and methods are provided that increase the sensitivity of optical particle counters and enable the detection of smaller particles while analyzing larger fluid volumes. The described systems and methods allow for sensitive and accurate detection and size characterization of nanoscale particles (eg, less than 50 nm, optionally less than 20 nm, optionally less than 10 nm) for large quantities of analyzed fluids.