Indomethacin n-methyl-d-glucamine salt - with anti-inflammatory activity with reduced side effects and improved water-solubility

摘要

Title salt, which is prepared by reacting indomethacin (1-(p-chlorbenzoyl)-5-methoxy-2-methylindole-3-acetic acid) in anhydrous medium (pref. in anhydrous EtOH) with N-methyl-D-glucamine, has better- anti-inflammatory activity and reduced side effects over indomethacin and is partic. suitable for incorporation into liquid preps. for oral or parenteral administration. Injections of the salt are painless, local necrosis does not occur, and high and long-lasting blood levels are obtd. the salt is hydrolysed in the circulatory system to give free indomethacin, so that it can be used for the same therapeutic indications as indomethacin.