首页>
外国专利>
Indomethacin n-methyl-d-glucamine salt - with anti-inflammatory activity with reduced side effects and improved water-solubility
Indomethacin n-methyl-d-glucamine salt - with anti-inflammatory activity with reduced side effects and improved water-solubility
展开▼
机译:吲哚美辛n-甲基-d-葡糖胺盐-具有消炎活性,具有减少的副作用和改善的水溶性
展开▼
页面导航
摘要
著录项
相似文献
摘要
Title salt, which is prepared by reacting indomethacin (1-(p-chlorbenzoyl)-5-methoxy-2-methylindole-3-acetic acid) in anhydrous medium (pref. in anhydrous EtOH) with N-methyl-D-glucamine, has better- anti-inflammatory activity and reduced side effects over indomethacin and is partic. suitable for incorporation into liquid preps. for oral or parenteral administration. Injections of the salt are painless, local necrosis does not occur, and high and long-lasting blood levels are obtd. the salt is hydrolysed in the circulatory system to give free indomethacin, so that it can be used for the same therapeutic indications as indomethacin.
展开▼