method for the preparation of a derivative of tolypomy - cinon or 16,17 - dihydrotolypomycinon, method of working reiden of therapeutic preparations which contain the derivative.preparation and formed.

摘要

Cpds. of formula (I) are new: (where R is opt. substd aliphatic hydrocarbyl, the C chains opt. being interrupted by O,S and/or N atoms(s); Q is -CH=C(CH3)-; -CH2CH(CH3)- or -CH2- (CH3)-; the gps. are pref. both the same). (I) are antibiotics and are more stable in acid medium than Tolypomycin Y and better activity than tolypomycinone. They are bactericides with activity against Gram positive and -negative bacteria and are useful for treating infections in animals and man. Their stability towards acids makes them suitable for oral administration. (I) are useful in treatment of pneumonia, digestive tract infections and various types of abscess.