首页> 外国专利> METHOD OF OBTAINING OF ISOTHIASOLCARBOXAMIDS OF 6- (M- AMINOPHENYL) - 2,3,5,6- TETRAHYDROIMIDAZO- (2,1- B) THIASOL- (M- AMINOTETRAMISOL)

METHOD OF OBTAINING OF ISOTHIASOLCARBOXAMIDS OF 6- (M- AMINOPHENYL) - 2,3,5,6- TETRAHYDROIMIDAZO- (2,1- B) THIASOL- (M- AMINOTETRAMISOL)

机译:获得6-(M-氨基苯基)-2,3,5,6-四羟基咪唑啉-(2,1- B)噻唑醇-(M-氨基四胺)的异硫酚甲酰胺的方法

摘要

The 1- and dl-(racemic) forms of the compounds of the formula ...(I), wherein R is H or CH3, and the non-toxic acid addition salts thereof, useful as anthelmintic compounds are disclosed. The compounds may be prepared by reacting 1- or dl6-(m-aminophenyl)-2,3,5,6-tetrahydroimidazo¢2,1-b!thiazole with an acid of the formula ...(III), wherein R is H or CH3, or with its functional equivalent as an acylating agent, and if desired, when the dl- form of the thiazole starting material is used, resolving the dl- product so as to obtain the 1- form, and if desired, converting an 1- or dl- form of a compound of the Formula (I), into a non-toxic addition salt by reaction with a suitable acid.
机译:公开了用作驱虫药的式(I)化合物的1-和dl-(外消旋)形式及其无毒酸加成盐,其中R为H或CH 3。可以通过使1-或dl6-(间氨基苯基)-2,3,5,6-四氢咪唑基2,1-噻唑与式(III)的酸反应来制备化合物,其中R是H或CH 3,或者其功能等同物作为酰化剂,并且如果需要,当使用噻唑原料的dl-形式时,将dl-产物拆分为1-形式,如果需要,通过与合适的酸反应将式(I)的化合物的1-或dl-形式转化为无毒的加成盐。

著录项

  • 公开/公告号BG28420A3

    专利类型

  • 公开/公告日1980-04-15

    原文格式PDF

  • 申请/专利权人 PFIZER;

    申请/专利号BG19770037642

  • 发明设计人 LEEMING;STUBBS;

    申请日1977-10-21

  • 分类号C07D277/60;

  • 国家 BG

  • 入库时间 2022-08-22 18:39:57

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