Novel ergolinyl compounds nitrogen-substituted in the 8-position, their preparation, and use as medicinal agents

摘要

Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) CHEM and physiologically compatible salts thereof, wherein (a) R1 is hydrogen, the 8-substituent can be in the alpha - or beta -position and CHEM represents a single or double bond. R2 is hydrogen, C1 4-alkyl or C1 7-acyl, R3 is hydrogen, chlorine or bromine, and R4 is C1-6-alkyl, C3-6-cycloalkyl-C1-3-alkyl, C3 6-alkenyl, or C3-6-alkynyl; or (b) R1 is -@-NR5R6, and the 8-substituent can be in the alpha - or beta -position, CHEM represents a single or double bond, R2, R3 are as defined above, R4, is C1-6-alkyl, C3-6-cycloalkyl-C1-3-alkyl, C3-6-alkenyl, or C3-6-alkynyl; and R5 is hydrogen, C1-10-alkyl, C3 10-alkenyl, or C3 10-alkynyl, and R6 is C1-10-alkyl, C3-10-alkenyl, C3-10-alkynyl, or aryl, or R5 and R6 together with the connecting N-atom form a 5- to 10-membered heterocyclic ring, preferably 5- or 6-membered, which optionally can contain further heteroatoms.