首页> 美国政府科技报告 >Addition Compounds of Alkali Metal Hydrides. 31. Preparation and Properties of Chiral Dialkoxymonoalkylborohydrides. A New Class of Asymmetric Reducing Agents
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Addition Compounds of Alkali Metal Hydrides. 31. Preparation and Properties of Chiral Dialkoxymonoalkylborohydrides. A New Class of Asymmetric Reducing Agents

机译:碱金属氢化物的加成化合物。 31.手性二烷氧基单烷基硼氢化物的制备和性质。一类新的不对称还原剂

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Recently we have established the general synthesis of a series of trisubstituted borohydrides, such as trialkylborohydrides A, trialkoxyborohydrides B, dialkylmonoalkoxyborohydrides C, and dialkoxymonoalkylborohydrides D. Among these trisubstituted borohydrides, the general synthesis of mixed trisubstituted borohydrides C and D have been accomplished by using cyclic moieties, such as 9-BBN in C and glycols in D, to stabilize the products toward disproportionation. Class D reagent appeared to be highly attractive for chiral borohydrides since various chiral diols are readily available, and moreover, chiral diols containing a C2 axis of symmetry can be incorporated. However, no work has been done on exploring the possible utilities of these dialkoxymonoalkylborohydrides D, as asymmetric reducing agents. Therefore, we undertook the study of the syntheses of various chiral dialkoxymonoalkylborohydrides and their asymmetric reducing characteristics toward selected prochiral ketones. Reprints.

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