Composite salmonella E. coli, Vibrio cholerae vaccine strains

摘要

Composite bacterial strains useful as vaccines for the prophylactic treatment of enteric diseases are hybrids of Salmonella and E. coli in which E. coli-derived lipopolysaccharide cores expressed in a Salmonella organism serve as a scaffold upon which the O-antigen of yet another pathogenic bacterial species, such as Vibrio cholerae is constructed. Such strains, methods of their production, vaccine compositions comprising these strains, and methods of treating enteric disease with these vaccine compositions, are disclosed.