Covalent conjugates of lipids and oligonucleotides.

摘要

It ARISES where it engages a conjugated covalently a lipid to an oligonucleotide sequence which is well INTEREST OR substantially complementary to a nucleotide sequence of interest. The conjugate is useful for nucleic acid purification, diagnostic, AND THERAPEUTIC APPLICATIONS. It INCLUDES THE THERAPEUTIC APPEARANCE IN WHICH CONJUGADOS oligonucleotide contains a nucleotide sequence antisense to a sequence encoding a polypeptide RESPONSIBLE pathogenetic DISORDER.