Preparation of human myelomonocyte interferon-gamma

摘要

The present invention relates to a novel human interferon- gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte interferon- gamma has a novel polypeptide and carbohydrate chain structure, and it is effective in preventing and treating viral diseases, malignant tumors and immunopathies alone or in combination with other lymphokine and/or chemotherapeutic. The human myelomonocyte interferon- gamma may be produced by culturing an established human myelomonocyte on a culture medium in vitro. Alternatively, an established human myelomonocyte is implanted in a non-human warm-blooded animal or in a diffusion chamber placed inside or outside the body of the animal, and then allowed to proliferate while receiving nutrient body fluid from the animal. The human myelomonocyte may be contacted with an inducer during propagation.